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  1. It has no effect on coronary sinus blood flow, myocardial oxygen consumption, and myocardial lactate extraction, and it does not increase intracranial pressure buy accutane online canada A major unresolved issue concerns whether this tissue tropism simply reflects a passive process whereby CTCs arrest within capillary beds due to the layout of the vasculature and size restrictions imposed by blood vessel diameters or, instead, indicates a capacity of CTCs to actively home to specific organs via genetically templated ligand receptor interactions between these cells and the luminal walls of the microvasculature

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